Percutaneous CT guided cryovagotomy for the management of mild - moderate obesity: a pilot trial.

Presented During:

Sun, 3/18/2018: 4:20 PM  - 4:30 PM 
Los Angeles Convention Center  
Room: 406A  

Final ID:

2186 

Type:

Late Breaking - Original Scientific Research-Oral or Poster 

Authors:

J Prologo1, S Cole2, S Horesh Bergquist2, D Corn3, J Knight4, H Matta5, A Singh2, E Lin6

Institutions:

1Emory University School of Medicine, Division of Interventional Radiology and Image Guided Medicine, Atlanta, GA, 2Emory University School of Medicine, Atlanta, GA, 3University At Buffalo, Buffalo, NY, 4Emory Healthcare, Roswell, GA, 5Penn State University Milton S. Hershey Medical Center, United States, 6Emory University School of Medicine, Department of Surgery, Atlanta, GA

First Author:

J. David D. Prologo, MD, FSIR  
Emory University School of Medicine, Division of Interventional Radiology and Image Guided Medicine
Atlanta, GA

Co-Author(s):

Stephen Scott Cole, M.D.  
Emory University School of Medicine
Atlanta, GA
Sharon Horesh Bergquist, MD  
Emory University School of Medicine
Atlanta, GA
David J Corn  
University At Buffalo
Buffalo, NY
Jacquelyn Knight, NP  
Emory Healthcare
Roswell, GA
Hazem M. Matta, DO  
Penn State University Milton S. Hershey Medical Center
United States
Arvinpal Singh  
Emory University School of Medicine
Atlanta, GA
Edward Lin  
Emory University School of Medicine, Department of Surgery
Atlanta, GA

Presenting Author:

J. David D. Prologo, MD, FSIR  
Emory University School of Medicine, Division of Interventional Radiology and Image Guided Medicine
Atlanta, GA

Purpose:

To evaluate the safety and feasibility of percutaneous CT guided cryoablation of the posterior vagal trunk in subjects with mild to moderate obesity.

Materials:

Ten subjects (8 female, 2 male, mean age 44 ± 12 years [range 27-66]) with 30 > BMI > 37 underwent percutaneous CT guided cryoablation of the posterior vagal trunk along the distal esophagus on the right. Following an initial consultation and the procedure, each subject received a 24-hour phone call and followed up with a clinic visit on days 7, 45, and 90, post procedure. Subjects were primarily evaluated for identification of procedure related complications or adverse events. Anthropometric measurements were obtained at baseline and at each follow up visit. In addition, each subject was administered a Patient Global Impression of Change Tool for evaluation of appetite.

Results:

The technical success rate was 100%. There were no procedure related complications. There were no adverse events during follow up. The average total weight loss (TWL) and excess BMI lost (EBMIL) were 3.6% and 13.9%, respectively, at 90 days. (Table) All patients reported decreased appetite at all follow up points after the procedure (n=30): 17% reported "somewhat less appetite," 30% reported "much less appetite," and 53% reported "very much less appetite."

Conclusions:

Percutaneous CT guided cryoablation of the posterior vagal trunk was feasible and safe in this pilot cohort of subjects with mild or moderate obesity. All subjects reported decreased appetite for 90 days following the procedure, and all subjects lost weight.

Abstract Categories:

Non-Vascular Interventions: Other

Keywords:

Cryoneurolysis
Obesity
weight loss

  Day 7 Day 45 Day 90
Average EBMIL 4.5% 9.7% 13.9%
Average TWL 1.1% 2.5% 3.6%
Number of Patients Reporting Decreased Appetite 100% 100% 100%