SIR 2024
Pain Management/MSK
Ahmed Mahran, MD
Research Post Doc
University Health Network, Canada
Financial relationships: Full list of relationships is listed on the CME information page.
Kieran Murphy, MD (he/him/his)
professor
University Health Network, Canada
Financial relationships: Full list of relationships is listed on the CME information page.
We leveraged the Peltier effect, the temperature difference created by an electric current flowing through two distinct semiconductors to achieve thermoelectric cooling. Our cryoprobe design incorporated these semiconductors between ceramic plates, facilitating efficient heat transfer. Importantly, we integrated a heat pipe into the probe as the needle, which transported the cryogenic temperatures from the thermoelectric module to the needle tip. This design allowed rapid and effective transfer of cold temperatures to the target site. The methodological advantage of thermoelectric cryoneurolysis lies in its reversibility. By simply altering the direction of the current flow, the hot and cold surfaces of the probe can be switched, thus enabling rapid tissue freezing and thawing during the procedure. This flexibility may enhance the clinical applicability of cryoneurolysis, providing more control over the procedure.
Results:
Initial experimental evaluations demonstrated its ability to regulate and fluctuate the temperature of the cryoprobe tip in the therapeutic ranges. The cooling phase reached suitable freezing temperatures, adequate to induce axonotmesis. Subsequently, the probe tip was able to thaw the affected area and further facilitate effective treatment. The repeatable cycles of freezing and warming showed the system's capability in managing precise temperature control, proving the potential for a consistent, targeted approach in pain management therapy.
Conclusion:
The proposed cryoablation device utilizing the thermoelectric effect shows promise for providing enhanced, efficient, and controlled pain relief in interventional pain therapy.