SIR 2024
Portal Hypertension
Achintya Patel, MD
Resident
Atrium Health Wake Forest Baptist
Financial relationships: Full list of relationships is listed on the CME information page.
Harun Krndzija, BS
Medical Student
Augusta University's Medical College of Georgia
Disclosure information not submitted.
Thomas Sullivan, MD
Assistant Professor
Atrium Health Wake Forest Baptist
Financial relationships: Full list of relationships is listed on the CME information page.
Moaz M. Choudhary, MD
Assistant Professor of Radiology
University of Texas Southwestern Medical Center
Financial relationships: Full list of relationships is listed on the CME information page.
A total of 25 patients were treated with Onyx from 2019 to 2023. The average age was 62.4 years old (SD 10.2) and were 48% male. Of the initial 25 patients, 24 patients had follow-up within 3 months of the procedure and 14 patients had follow-up within 6-12 months. The remaining patients were lost to follow-up or deceased. The average PLTs in the pre procedure group was 69.5 (SD 35.2), in the early follow up group was 178.5 (SD 149.8), and in the late follow up group was 158.4 (SD 95.8). There was a statistically significant increase in PLTs between pre-procedure vs the early follow up groups [t(47) = 3.47, p < 0.01] and the pre-procedure vs the late follow up groups [t(37) = 3.34, p < 0.01]. There was no significant difference between the early follow up and late follow up groups [t(36) = 0.51, p = 0.31]. Within 30 days of the procedure, 13 patients (52%) experienced post-embolization syndrome, categorized as mild adverse events per SIR criteria and comparable to reported complication rates {1}. Additionally, one patient was noted to have small volume hemoperitoneum that was managed conservatively, also considered a mild adverse event.
Conclusion: Partial splenic artery embolization using Onyx is safe and effective, resulting in statistically significant increases in PLTs which appears to persist in the 6-12 month follow up cohort.