SIR 2024
Transplant Interventions
Varun Singh, MD
Interventional Radiology Resident Physician
Massachusetts General Hospital
Financial relationships: Full list of relationships is listed on the CME information page.
Brandon Gaston, MD
Resident Physician
Massachusetts General Hospital
Disclosure information not submitted.
Anil Kharga, MD
Research Assistant
Massachusetts General Hospital
Disclosure information not submitted.
Kevin Deng, BS
Research Assistant
Massachusetts General Hospital
Disclosure information not submitted.
Kang MI Lee, PhD
Research Scientist
Massachusetts General Hospital
Disclosure information not submitted.
James F. Markmann, MD, PhD
Chief, Division of Transplantation
Massachusetts General Hospital
Disclosure information not submitted.
Sanjeeva P. Kalva, MBBS, MD, RPVI, FSIR, FCIRSE, FACR (he/him/his)
Professor
Massachusetts General Hospital
Financial relationships: Full list of relationships is listed on the CME information page.
Murine islet cells within immunoisolated semipermeable stents in a perfused ex-vivo environment secrete insulin in response to glucose stimulation in a statistically significant fashion. These results demonstrate free diffusion of glucose and insulin across a semipermeable PTFE membrane small enough to exclude large immunoglobulins and mediators of cellular immunity. These findings represent significant promise of an image-guided islet cell stent transplantation obviating the need for immunosuppression, potentially superior to standard islet cell transplantation. Future studies will explore in vivo immunoisolation in a non-human primate portal venous diabetes model.