554 - Outcomes of Lung Ablation in Patients with Soft Tissue Sarcoma with Pulmonary Metastasis

Purpose: The purpose of this study is to evaluate the outcomes of lung cryoablation for metastatic sarcoma, focusing on technical success, overall survival, and local tumor recurrence in patients with varying numbers of pulmonary metastases treated between November 2020 and August 2025.

Materials and Methods: Between November 2020 and August 2025, 23 patients were treated for metastatic sarcoma. No extra-pulmonary metastasis were noted for 15 patients. 9 patient had 1 metastasis, 6 patients had 2 metastasis, 4 had 3 metastasis, 2 patients had 4 metastasis, 1 each had 5 and 6 pulmonary metastasis respectively. The endpoints were: technical success (assessed by CT images during and after the procedure), overall survival and local tumor recurrence.

Results: A total of 38 metastasis in 23 patients underwent cryoablation. The median tumor diameter was 20 mm (range 8-42). Lung cryoablation was performed under general anesthesia with CT guidance. Median follow-up time was 25 months. Technical success was achieved in 35 cases of tumor ablation (92.1%). The 1 and 3-year OS rates were 91.3% and 65.2% A total of 7 recurrence were noted on cryoablation sites.

Conclusion: Cryoablation is safe and effective in the treatment of pulmonary metastases arising from soft tissue sarcoma.