171 - Liver Venous Deprivation versus Portal Vein Embolization for Future Liver Remnant Hypertrophy: A Meta-Analysis

Monday, April 13, 2026

3:18 PM - 3:27 PM ET

Presenting Author(s)

JW

Jonathan Wang, MD

Resident Physician
University of Chicago, United States

Author/Co-author(s)

PT

Patrick Tran, MD

Resident Physician
University of Chicago, United States
TV

Thuong Van Ha, MD

Professor
University of Chicago, United States
Rakesh C. Navuluri, MD, FSIR

Associate Professor
University of Chicago, United States
CY

Clark Yu, MD

Physician
University of Chicago, United States

Purpose: Liver venous deprivation (LVD) has emerged as a technique to improve future liver remnant (FLR) hypertrophy, combining hepatic vein embolization (HVE) with portal vein embolization (PVE) prior to major hepatectomy. This meta-analysis aims to evaluate the safety and efficacy of LVD compared to PVE alone using available comparative studies.

Materials and Methods: A comprehensive literature search was conducted up to September 2025, identifying 16 eligible comparative studies including 416 patients in the LVD group and 783 in the PVE-only group. Pooled outcomes included FLR volume, percentage FLR hypertrophy, kinetic growth rate (KGR), post-embolization resectability, and major post-resection adverse events. Effect estimates were reported as odds ratios (ORs) and standardized mean differences (SMDs) with 95% confidence intervals (CIs). Publication bias was assessed using funnel plots and Egger’s test.

Results: Compared to PVE alone, LVD resulted in significantly greater FLR volume (SMD: 628.6, 95%CI: 533.1-724.1, p< 0.001), percentage FLR hypertrophy (SMD:39.7, 95%CI: 35.0-44.3, p< 0.001), and KGR (SMD: 2.0, 95%CI: 1.7-2.4, p< 0.001). The overall rate of resection failure (OR: 1.6, 95%CI: 0.8-2.8, p=0.163) and that due to insufficient FLR (OR:1.4, 95%CI: 0.7-2.9, p=0.385) were comparable between groups. No significant difference was observed in the incidence of major post-resection adverse events (OR: 1.1, 95%CI: 0.7-1.6, p=0.759).

Conclusion: LVD appears to be more effective than PVE alone in promoting FLR hypertrophy, without increasing the risk of major postoperative complications.