12 - In Vivo Feasibility of Arterial Embolization with a slurry comprising agar-agar agent (Embobio®)

Monday, March 31, 2025

12:10 PM – 1:10 PM CT

Location: Music City Center, Expo Poster Area

Poster Presenter(s)

Thibault Agripnidis, MD

Dr
Interventional Radiology Section, Department of Medical Imaging, University Hospital Timone, AP-HM, France

Author/Co-author(s)

AR

Alexis Ruimy, MD

Dr
Interventional Radiology Section, Department of Medical Imaging, University Hospital Timone, AP-HM, France
JN

Johanna Nguyen, None

Aix Marseille University, LIIE, Marseille, France.
Aix Marseille University, CERIMED, Marseille, France., France
PB

Pauline BRIGE, PhD

Aix Marseille University, LIIE, Marseille, France.
Aix Marseille University, CERIMED, Marseille, France, France
BG

Benjamin Guillet, PhD

Pr
Aix Marseille University, CERIMED, Marseille, France. Aix-Marseille University, INSERM 1263, INRAE 1260, C2VN, Marseille, France. Department of Nuclear Medicine, Aix-Marseille University, Assistance Publique-Hôpitaux de Marseille (AP-HM, France
VV

Vincent Vidal, MD, PhD

Pr
University Hospital Timone, France

Purpose:

The EmboBio® project aims to develop an agar-agar based embolization agent for intra-arterial embolization resulting from a biological process that respects the ecosystem and is low cost.

Materials and Methods:

A group of six pigs underwent embolization of polar renal artery and lumbar artery with agar-agar slurry. Technical success was defined as an occlusion of the target artery with no residual flow in Digitalized Substracted Angiography (DSA). The short-term secondary endpoints were the safety (non-targeted embolization and reproducible fragment size) and the ease of use by an evaluation of the embolization preparation time, and time of occlusion.

Results:

For agar-agar slurry technical success was obtained for all slurry kidney and lumbar embolization with satisfactory devascularisation of the target. No off-target embolization was observed in kidney and lumbar embolization. The time to total occlusion after arterial release by agar-agar slurry is fast with a mean time of 4,33 seconds for kidney embolization and 5,33 seconds for lumbar embolization. Product preparation was quick and easy, with a mean preparation time of 245 seconds for kidney embolization and 185 seconds for lumbar embolization. The fragmentation method to create slurry was reproducible and easy to set up, with size of the particles used for embolization following a normal distribution.

Conclusion:

Embolization by agar-agar slurry is a feasible, fast and effective treatment which opens the possibility of global use of this new embolization agent.