Skip to main content
SIR 2025 Event Main banner
BSCI - Consideration Cases Ad 1
Merit/DPSSME Siege
Back

SIR 2025

Arterial Interventions

Traditional Poster

Session: Traditional Poster Presentations

1 - Comparison of N-Butyl-2-Cyanoacrylate versus Polyvinyl Alcohol in Bronchial Artery Embolization; A Pilot Systematic Review and Meta-Analysis

Monday, March 31, 2025
12:10 PM – 1:10 PM CT
Location: Music City Center, Expo Poster Area
Purpose: N-butyl-2-cyanoacrylate (NBCA) and Polyvinyl Alcohol (PVA) particles are polymers used as tissue adhesives in Bronchial artery embolization (BAE). The safety and efficacy of these interventions is still debatable. The purpose of this study is to focus on the outcomes and complications associated with the PVA and NBCA in BAE which can help evaluate the safety and efficacy of these interventions.

Materials and Methods:

A systematic review and meta-analysis were conducted according to PRISMA guidelines after a thorough literature search on the following databases: MEDLINE (via PubMed), EMBASE, and Cochrane Library. Observational studies and Randomized Control Trials (RCTs) studying the comparison of PCA with NBCA in bronchial artery embolization were included. Six outcomes were analyzed with clinical success as the primary outcome and complications, mortality, recanalization, technical success, and recurrence as the secondary outcome. Revman 5.4 was used to perform the meta-analysis and construct forest plots. For the evaluation of dichotomous data Risk Ratios (RR) were used and a p-value of less than 0.05 was considered statistically significant. Publication bias was assessed by visual inspection of DOI plots.

Results:

A total of 4 studies including one RCT and three observational studies with a combined sample size of 772 participants were pooled together. The NBCA group was superior to the PVA group in terms of clinical success [RR: 1.12; 95% CI:1.01 – 1.26; p=0.04; I2=80%]. Similarly, for recanalization [RR: 0.38; 95% CI:0.20–0.72; (p=0.003); I2=0%] and recurrence [RR: 0.33; 95% CI:0.15– 0.76; (p=0.009); I2=70%], the NBCA group was statistically superior to PVA group. However, technical success groups [RR: 1.01; 95% CI:0.98– 1.05; (p=0.43); I2=53%], mortality [RR: 0.60; 95% CI:0.13 – 2.78; (p=0.51); I2=0%] and complications [RR: 1.42; 95% CI:0.56 – 3.59; (p=0.46); I2=89%] were comparable to each other in both the groups.

Conclusion: The NBCA group showed a low recurrence rate, recanalization, and higher clinical success rate compared to the PVA group. However, there is still a need for more large-scale randomized controlled trials to provide robust evidence to support these findings.