SIR 2024
General IR
Kong Teng Tan, MD, FRCPC
Former Head of Interventional Radiology
Toronto General Hospital, CAN
Disclosure information not submitted.
Sean Lau, BSc, MSc
Research Coordinator
University Health Network, Canada
Disclosure information not submitted.
Kieran Murphy, MD (he/him/his)
professor
University Health Network, Canada
Financial relationships: Full list of relationships is listed on the CME information page.
Physicians and staff performing image guided therapeutic procedures sustain Nuclear and Mitochondrial DNA damage. Over a career an interventionalist may accumulate over 1 Gray of lifetime exposure. Complex fenestrated EVAR and Interventional neuro procedures are associated with particularly high patient and physician radiation exposures.
We have developed DNA Halo, an antioxidant formulation as a premedication that protects both the Cell Nuclear and mitochondrial DNA. It is FDA and Health Canada approved. We studied this in a 3-arm randomized study, and the results were analyzed by 2 separate blinded labs.
Materials and Methods:
With IRB approval, and informed consent, we studied 20 physicians performing image guided therapy over a 3-week period. These Interventional radiologists, interventional Neuroradiologists and vascular surgeons agreed to six 20cc blood draws.
Week 1: 20 Subjects, blood drawn on Monday morning and Friday evening, no premedication.
Week 2: 2 groups of 10 MDs, randomized to placebo vs premedication for one day. Premedicated subjects took 2 DNA Halo pills 1 hour before starting their cases.
Week 3: 20 subjects, blood drawn on Monday morning and Friday evening, with daily premedication. All subjects took 2 DNA Halo pills each morning.
The specimens were split into 2 groups and analyzed at UHN Toronto and McMaster Hamilton, Ontario.
We analyzed Nuclear DNA with P53 tests and Mitochondrial DNA and RNA with STAT 3, NFkB, COX4/1 tests.
Results:
Premedication with DNA Halo resulted in a 72% decrease in observed vs expected Nuclear DNA damage as measured with P53 tests. (p< 0.01)
DNA Halo premedication reduced Mitochondrial DNA damage by 54% in observed vs expected Mitochondrial DNA damage as measured with STAT3 tests, 44% as measured by NFkB, and 46% as measured by COX4/1. (p< 0.01).
Conclusion:
Conclusion:
DNA Halo is effective in reducing both Nuclear and Mitochondrial DNA from radiation. Mitochondrial protection from radiation has never been shown before. Mitochondrial DNA is inherited purely maternally. This study has implications for patients undergoing diagnostic and interventional radiological procedures and the medical teams performing them.